APA
Click to copy
Lehmann, J., Thelen, M., Kreer, C., Schran, S., Garcia-Marquez, M., Cisic, I., … Schlößer, H. A. (2024). Tertiary lymphoid structures in pancreatic cancer are structurally homologous, share gene expression patterns and B-cell clones with secondary lymphoid organs but show increased T-cell activation. Cancer Immunology Research.
Chicago/Turabian
Click to copy
Lehmann, J., M. Thelen, Christoph Kreer, S. Schran, M. Garcia-Marquez, Igor Cisic, Klara Siepmann, et al. “Tertiary Lymphoid Structures in Pancreatic Cancer Are Structurally Homologous, Share Gene Expression Patterns and B-Cell Clones with Secondary Lymphoid Organs but Show Increased T-Cell Activation.” Cancer immunology research (2024).
MLA
Click to copy
Lehmann, J., et al. “Tertiary Lymphoid Structures in Pancreatic Cancer Are Structurally Homologous, Share Gene Expression Patterns and B-Cell Clones with Secondary Lymphoid Organs but Show Increased T-Cell Activation.” Cancer Immunology Research, 2024.
BibTeX Click to copy
@article{j2024a,
title = {Tertiary lymphoid structures in pancreatic cancer are structurally homologous, share gene expression patterns and B-cell clones with secondary lymphoid organs but show increased T-cell activation.},
year = {2024},
journal = {Cancer immunology research},
author = {Lehmann, J. and Thelen, M. and Kreer, Christoph and Schran, S. and Garcia-Marquez, M. and Cisic, Igor and Siepmann, Klara and Hagen, Elena M and Eckel, H. and Lohneis, P. and Kruger, Stephan and Boeck, Stefan and Ormanns, Steffen and Rudelius, Martina and Werner, Jens and Popp, Felix and Klein, Florian and von Bergwelt-Baildon, Michael and Bruns, Christiane J. and Quaas, A. and Wennhold, K. and Schlößer, Hans A}
}
Tertiary lymphoid structures (TLS) in cancer are considered ectopic hotspots for immune activation that are similar to lymphoid follicles in secondary lymphoid organs (SLO). This study elucidates shared and TLS/SLO-specific features in pancreatic ductal adenocarcinoma (PDAC). TLS abundance was related to superior survival and T-cell abundance in 110 treatment-naïve PDAC samples, underlining their clinical relevance. Immunofluorescence microscopy identified structural homologies between TLS and SLO. In RNA-expression analyses of laser-microdissected TLS and paired SLOs, we observed largely overlapping expression patterns of immune-related gene clusters, but distinct expression patterns of T-cell and complement-associated genes. Immune cells in TLS expressed essential markers of germinal center formation. Increased activation of tumor-draining lymph nodes in patients with high numbers of TLS highlights the relevance of these tumor-related structures to systemic immune response. In line with this, we identified an overlap of expanded B-cell receptor clonotypes in TLS and SLO, which suggests a vivid cross-talk between the two compartments. . We conclude that combined therapeutic approaches exploiting TLS-mediated antitumor immune responses may improve susceptibility of PDAC to immunotherapy.