APA
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Thelen, M., Wennhold, K., Lehmann, J., Garcia-Marquez, M., Klein, S., Kochen, E., … Schlößer, H. (2021). Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy. Npj Precision Oncology.
Chicago/Turabian
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Thelen, M., K. Wennhold, J. Lehmann, M. Garcia-Marquez, Sebastian Klein, Elena Kochen, P. Lohneis, et al. “Cancer-Specific Immune Evasion and Substantial Heterogeneity within Cancer Types Provide Evidence for Personalized Immunotherapy.” npj Precision Oncology (2021).
MLA
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Thelen, M., et al. “Cancer-Specific Immune Evasion and Substantial Heterogeneity within Cancer Types Provide Evidence for Personalized Immunotherapy.” Npj Precision Oncology, 2021.
BibTeX Click to copy
@article{m2021a,
title = {Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy},
year = {2021},
journal = {npj Precision Oncology},
author = {Thelen, M. and Wennhold, K. and Lehmann, J. and Garcia-Marquez, M. and Klein, Sebastian and Kochen, Elena and Lohneis, P. and Lechner, A. and Wagener-Ryczek, S. and Plum, P. and Camacho, Oscar Velázquez and Pfister, D. and Dörr, F. and Heldwein, M. and Hekmat, K. and Beutner, D. and Klussmann, J. and Thangarajah, F. and Ratiu, D. and Malter, W. and Merkelbach-Bruse, S. and Bruns, C. and Quaas, A. and von Bergwelt-Baildon, M. V. and Schlößer, H.}
}
The immune response against cancer is orchestrated by various parameters and site-dependent specificities have been poorly investigated. In our analyses of ten different cancer types, we describe elevated infiltration by regulatory T cells as the most common feature, while other lymphocyte subsets and also expression of immune-regulatory molecules on tumor-infiltrating lymphocytes showed site-specific variation. Multiparametric analyses of these data identified similarities of renal and liver or lung with head and neck cancer. Co-expression of immune-inhibitory ligands on tumor cells was most frequent in colorectal, lung and ovarian cancer. Genes related to antigen presentation were frequently dysregulated in liver and lung cancer. Expression of co-inhibitory molecules on tumor-infiltrating T cells accumulated in advanced stages while T-cell abundance was related to enhanced expression of genes related to antigen presentation. Our results promote evaluation of cancer-specific or even personalized immunotherapeutic combinations to overcome primary or secondary resistance as major limitation of immune-checkpoint inhibition.